Perkhidmatan pengubahsuaian peptida
Pengubahsuaian peptida mengubah sifat fizikal dan kimia peptida dengan mengubah suai rantai utama dan struktur rantai sisi peptida, dengan itu meningkatkan bioavailabilitinya. Ubat peptida yang diubah suai dengan ketara boleh mengurangkan imunogenisiti, mengurangkan kesan toksik, meningkatkan keterlarutan air, memanjangkan masa tindakan dalam badan, mengubah pengedaran dalam badan, dsb. Pengubahsuaian peptida biasa termasuk: Pengubahsuaian hujung C, pengubahsuaian Terminal N, pengubahsuaian sisa perantaraan dan pengubahsuaian kitaran.
N akhir pengubahsuaian
| •Ac | •Allyl | •Kolesteril- | •N-Propargylglycine- |
| •Fmoc | •Akrilik | •Fruktosa- | •Iklan |
| •CBZ | •Peruntukkan | •Glukosa- | •BPS- |
| •Boc | •Pyr | •DMAP-Ac | •Morfolin-4-karbonil- |
| •Bz | •D-Pyr | •NTriAc | •Trans-Cinnamoyl |
| •Bz (5-NH2,2-NO2) | •LA- | •PhAc | •2-Furoyl |
| •Bz (4-F) | •Mpa- | •Py-Ac | •Methacryl- |
| •Bz (4-NO2) | •Tos | •N-Amidinoglycine | •BPA- |
C akhir pengubahsuaian
| •-pNA | •-Ome | •-ONP | •-OSu |
| •-NH2 | •-OEt | •-AMC | •-NHMe |
| •-ol | •-OBzl | •-AFC | •-NHEt |
Pengasidan lemak
|
•Untuk |
•MeOSuc |
•5-Asid heksinoik |
•F-Lau- |
|
•MeOCO |
•Iba |
•Asid heptanedioik |
•Myr- |
|
•2-Br-Ac |
•asid pentenoik |
•Okt- |
•F-Myr- |
|
•2-Cl-Ac |
•pentinoil |
•J-Okt- |
•Pentadeconyl- |
|
•2-I-Ac |
•Hex- |
•Dis- |
•Sahabat- |
|
•OH-Ac |
•asid 5-heptenoik |
•Asid sebacic |
•Cys (Sahabat) |
|
•3-Bromopropionyl |
•Trans-3-heksenoyl- |
•F-Dis- |
•Pam3C- |
|
•Tetapi- |
•Linoletik- |
•Undecyl- |
•Ste- |
|
•Suc |
•10,12-asid Pentacosadiynoic |
•Lau- |
•Asid oktanedioik |
Metilasi
| •Lys (Saya) | •Arg (Saya) | •Tyr (Saya) | •Tyr (Et) |
| •Lys (Me2) | •Arg (Me2) tidak simetri | •Thr (Saya) | •D-Tyr (Et) |
| •Lys (Me3) | •Arg (Me2) simetri | •Ser (Saya) |
Fosforilasi
| •pSer | •D-pSer | •Di-tapak dalam urutan | •4-tapak dalam urutan |
| • pTyr | •D-pTyr | •Tri-tapak dalam urutan | •5-tapak dalam urutan |
| •pThr | •H-pThr |
Peptida cawangan
| •Simetri 2 Cabang | •Simetri 4 Cabang | •Simetri 8 Cabang | •Lys simetri 2 Cawangan |
| •Lys simetri 4 Cawangan | •Lys simetri 8 Cabang | •Orn simetri 2 Cawangan | •Orn simetri 4 Cawangan |
| •Orn simetri 8 Cawangan | •Cawangan Glu 2 (Tulen) | •Gliserol 3 Cawangan ester | •Thr (Peptida2) |
| •Ser (Peptide2) | •Lys (Peptide2) |
Peptida kitaran
| •Jambatan Mono Disulfida | •Jambatan Disulfida Berganda | •Jambatan Tiga Disulfida | •Jambatan Triple Disulfide secara rawak |
| •Amide Cyclic (rantai sisi) oleh Lys | •Amide Cyclic (rantai sisi) oleh Orn | •Pengoksidaan antara Se-Cys |
•Amid Cyclic (hujung) |
| •Same Sequence Inter-Jambatan disulfida oleh pengoksidaan Cys | •Jambatan Antara Jujukan Berbeza-Disulfida oleh pengoksidaan Cys | ||
Pelabelan pendarfluor / pewarna
|
•Biotin- |
•FITC- |
•Dansyl- |
•Lys (Dnp) |
|
•DeThioBiotin |
•-ED-FITC |
•-EDDansyl |
•D-Lys (Dnp) |
|
•-EDBiotin |
•-Lys (FITC)- |
•-Lys (Dansyl)- |
•Dab (Dnp) |
|
•Glu (Biotin-PEG2) |
•-Lys (FITC) |
•-Lys (Dansyl) |
•Dap (Dnp) |
|
•-Lys (Biotin)- |
•Lys (Ahx-FITC) |
•Dansli-e-Lys |
•-EDDnp |
|
•-Lys (Biotin) |
•FITC-e-Lys |
•Dansyl-Ahx- |
•-Lys (LC-Biotin)- |
|
•FITC-Ahx- |
•5-FAM- |
•-Lys (LC-Biotin) |
•5-TAMRA- |
|
•5,6-FAM |
•Biotin-e-Lys |
•5 (6)-TAMTA- |
•6'FAM |
|
•Lys (S-S-Biotin) |
•-EDYAMRA |
•-ED-5-FAM |
•Biotin-Ahx- |
|
•-Lys (TAMRA)- |
•-Lys (5-FAM)- |
•Orn (Bio) |
•-Lys (5-TAMRA) |
|
•Lys (5,6-FAM) |
•MCA- |
•5-TAMRA-e-Lys |
•-Lys (5-FAM) |
|
•-Lys (MCA)- |
•5-TAMRA-Acp |
•5-FAM-E-Lys |
•-Lys (MCA) |
|
•5-FAM-Ahx- |
•Lys (MCA)- |
Gandingan BSA, KLH, OVA
| •BSA-Terminus Peptida N | •KLH-Peptida N terminal | •OVA-Peptide N terminal | •BSA-Terminus Peptida C |
| •KLH-Terminus Peptida C | •OVA-Terminus Peptida C | •BSA-Peptida melalui Cys | •KLH-Peptida melalui Cys |
| •OVA-Peptida melalui Cys |
Derivatif Phe & Tyr
|
•D-2-Cl-Phe |
•D-4-F-Phe |
•L-2-Me-Phe |
•L-3-I-Tyr |
|
•L-2-Cl-Phe |
•L-4-F-Phe |
•D-4-Me-Phe |
•D-3,5-DiI-Tyr |
|
•D-3-Cl-Phe |
•D-4-NO2-Phe |
•L-4-Me-Phe |
•L-3,5-DiI-Tyr |
|
•L-3-Cl-Phe |
•L-4-NO2-Phe |
•D-4-NH2-Phe |
•D-3-NO2-Tyr |
|
•D-4-Cl-Phe |
•D-4-I-Phe |
•L-4-NH2-Phe |
•L-3-NO2-Tyr |
|
•L-4-Cl-Phe |
•L-4-I-Phe |
•D-3-Cl-Tyr |
•D-3,5-DiNO2-Tyr |
|
•D-3,4-DiCl-Phe |
•D-3-CN-Phe |
•L-3-Cl-Tyr |
•L-3,5-DiNO2-Tyr |
|
•L-3,4-DiCl-Phe |
•L-3-CN-Phe |
•D-3,5-DiCl-Tyr |
•L-3-F-Tyr |
|
•D-4-Br-Phe |
•D-4-CN-Phe |
•L-3,5-DiCl-Tyr |
•L-4-NO2-Phg |
|
•L-4-Br-Phe |
•L-4-CN-Phe |
•D-3,5-DiBr-Tyr |
•D-4-NO2-Phg |
|
•D-3-F-Phe |
•D-2-Me-Phe |
•L-3,5-DiBr-Tyr |
•L-3,5-DiF-Phe |
|
•L-3-F-Phe |
•D-3-I-Tyr |
Penyambung
| •Gly | •Ava | •AEA | •GABA |
| •Beta-Ala | •Ahx | •Ado | •Mini-PEG |
| •Mini-PEG2 | •Mini-PEG3 | •PEG4 |
damar
| •peptida pada Wang Resin | •peptida pada 2-CTC Resin | •peptida pada Rink Amide AM Resin | •peptida pada Rink Amide MBHA Resin |
D asid amino
| •D-Ala | •D-Lys | •D-Glu | •D-Tyr |
| •D-Arg | •D-Met | •D-Gln | •D-Thr |
| •D-Asp | •D-Pro | •D-Nya | •D-Trp |
| •D-Asn | •D-Phe | •D-Leu | •D-Val |
| •D-Cys | •D-Ser |
Asid amino homotaip
|
•Har |
•HomoCit |
•beta-HomoMet |
•beta-HomoSer |
|
•D-Har |
•D-HomoCit |
•beta-HomoPro |
•beta-HomoThr |
|
•Hcy |
•HomoLeu |
•beta-HomoVal |
•beta-HomoTrp |
|
•HPh |
•HomoPro |
•beta-HomoAsp |
•beta-HomoTyr |
|
•D-HPh |
•D-HomoPro |
•beta-HomoAsn |
•Azidoomoalanine |
|
•Hse |
•beta-HomoIle |
•beta-HomoGlu |
•beta-HomoAla |
|
•D-Hse |
•beta-HomoLeu |
•beta-HomoGln |
•beta-HomoPhe |
Asid amino khas
|
•beta-Asp |
•3-Thi |
•D-Chg |
•Cys (pMeBzl) |
|
•D-beta-Asp |
•Aib |
•Ac6c |
•Cys (pMeOBzl) |
|
•gamma-Glu |
•Abu |
•Dab |
•Oic |
|
•D- gamma-Glu |
•D-Abu |
•Dap |
•Tic |
|
•Cys (Cam) |
• Hyp |
•Pra |
•D-Tic |
|
•D-Cys (Cam) |
•Ph |
•D-Pra |
•Cys (Bzl) |
|
•Cys (Acm) |
•D-Ph |
•Allo-Tr |
•Epsilon-Lys |
|
•Cys (tBu) |
•Nva |
•D-Allo-Thr |
•D-Epsilon-Lys |
|
•Cys (StBu) |
•D-Nva |
•Gly (allyl) |
•5-ASA |
|
•Bertemu (O) |
•Nle |
•D-Gly (allyl) |
•Bpa |
|
•D-Met (O) |
•D-Nle |
•Cys (Pyrene-maleimide) |
•Pip |
|
•Cys (SNO) |
•Cit |
•D-1-Nal |
•Nip |
|
•Bertemu (O)2 |
•D-Cit |
•L-1-Nal |
•2-Aze |
|
•D-Met (O)2 |
•Orn |
•D-2-Nal |
•3-Aze |
|
•Lys (Ac) |
•D-Atau |
•L-2-Nal |
•[Psi (CH2NH)] |
|
•Ac-Lys |
•Pen |
•D-2-Sahabat |
•[CS-NH] |
|
•Lys (Dde) |
•D-Pen |
•L-2-Sahabat |
•Se-Met |
|
•Tle |
•Cpg |
•D-3-Sahabat |
•Se-Cys |
|
•Ser (asid oktanoik) |
•Cha |
•L-3-kawan |
•DOPA |
|
•Ser (asid lipoik) |
•D-Cha |
•D-4-Sahabat |
•isoGln |
|
•D-Ser (asid oktanoik) |
•Chg |
•L-4-Sahabat |
•D-isoGln |
|
•Arg (Boc2) |
•Asp-OMe |
•D-Glu (OtBu) |
•Lys (Z) |
|
•Arg (NO2) |
•Asp-OtBu |
•Gln (Trt) |
•Ser (Bzl) |
|
•Arg (Z2) |
•Asn (Trt) |
•Nya (Boc) |
•Ser (Trt) |
|
•Arg (pbf) |
•Cys (MMt) |
•Nya (Trt) |
•Ser (tBu) |
|
•D-Arg (pdf) |
•Cys (Trt) |
•Tyr (propargil) |
•Tyr (tBu) |
|
•Asp (Oall) |
•D-Cys (Trt) |
•Lys (Boc) |
•Asp (OBn) |
|
•Glu (Oall) |
•Lys (DMT) |
•-Tyr (tBu) |
•Asp (OBzl) |
|
•Glu (OBzl) |
•Lys (Fomc) |
•Thr (tBu) |
•Asp (OMe) |
|
•Glu (OMe) |
•Lys (Mtt) |
•Trp (Boc) |
•Asp (OtBu) |
|
•Glu (OtBu) |
•Lys (Trt) |
•Trp (Farnesyl) |
Notis:
1. Maklumat di atas adalah untuk rujukan sahaja, dan keperluan pengubahsuaian peptida tersuai anda akan diserahkan kepada makmal untuk penilaian.
2. Jika anda mempunyai sebarang keperluan pengubahsuaian peptida yang tidak disenaraikan dalam jadual, anda boleh menghubungi kami terus untuk perundingan.